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can i get pregnant with cin 3

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He [consultant] said obviously it could mean that I was more likely to have a miscarriage, but he couldn’t say either way really. 197. A potential concern for women who deliver vaginally is local recurrence. • Infections can be transient or persistent. Anne Marie was worried about having another child after she had a haemorrhage following her cone biopsy. We normally say no tampons and no sex until the bleeding has completely settled down. I don't smoke and hardly ever drink. I would urge you to get a genuine second opinion from another OB/GYN or even a GYN oncologist. And a year later you were pregnant again? A cone biopsy poses a greater risk than LLETZ treatment. Neoadjuvant treatment has been shown to decrease the size of local tumors and facilitate surgical management. “Cervical cancer complicated by pregnancy: episiotomy site recurrences following vaginal delivery”. CIN 3 means the full thickness of the surface layer is affected. Husband' But again, though, this is one of those things that’s not in the information that you receive prior to the procedure. So, I guess it’s good to relax as well, which is not easy but it’s good to take a step back and actually realise you’re lucky rather than unlucky. vol. What signs and symptoms should make you concerned for invasive disease? But even if I’d had the worst sort of option, it would still have been possible, you know. Women with HSIL should not undergo ECC or an excisional procedure as part of their evaluation. How is treatment of cervical cancer made specific to pregnant women? “Intraepithelial” means that the abnormal cells are present on the surface (epithelial tissue) of the cervix. 298. First and foremost get treated, cervical dysplaisa's and cancers are very treatable so don't worry. Lancet. Economos, K, Perez Veridiano, N, Delke, I, Collado, ML, Tancer, ML. I'll keep you all posted xx. Already have an account? There wasn’t then. Some types of HPV can affect the quality and movement of your partner's sperm, leading to problems conceiving. What initial studies should you perform to help make the diagnosis? And that was down to me. “2006 consensus guidelines for the management of women with cervical intraepithelial neoplasia or adenocarcinoma in situ”. Atypical squamous cells of undetermined significance (ASC-US) is an abnormality that is frequently seen in young women. 48. In general, women diagnosed prior to 20-24 weeks of gestation are encouraged to receive immediate therapy, while those women diagnosed after 20-24 weeks may delay treatment until delivery which is typically planned at 32-34 weeks depending on the clinical scenario. Out of the 3, two came back with CIN III with endocervical crypt involvement. CIN 2 or greater will be detected in approximately 12-16% of women with LSIL. I think because I’d had a previous miscarriage it frightened me a bit more because it’s a scary thing to go through at any time and I just thought ‘could I go through that again’? 1073-8. vol. If this happened, you wouldn't be able to get pregnant naturally. 115. 2003. pp. Oh no, what a time to be getting this. The normal pregnant cervix is typically characterized by ectropion which may be accompanied by inflammation and may be mistaken as an abnormality. There is also about a 10% risk of preterm delivery that's associated with LEEP, though many people do go on to have healthy, full-term pregnancies. The management of cervical cancer during pregnancy depends primarily on the stage of the cancer and the gestational age of the mother at the time of diagnosis. Cervical cancer is staged using the 2009 International Federation of Gynecology and Obstetrics staging system. For these patients the timing of delivery should be coordinated with a multidisciplinary team including maternal-fetal medicine experts. “Surgical management of cervical cancer complicating pregnancy: a case-control study”. This is unlikely as there are many reasons why a woman may have a miscarriage. They found abnormal cells and I went back for a colposcopy only to find out the results today that I have CIN 3. What imaging studies (if any) will be helpful? So a stage I can progress to stage III by the end of pregnancy. CIN 3 is also known as carcinoma-in-situ. Posted 13/05/2011. How do you counsel the patient and family on prognosis of cervical cancer in pregnancy. While the lesion is poorly reproducible, the overall risk of cancer is low (between approximately 0.1-0.2%). Treatment for CIN / CGIN should not affect a woman’s ability to get pregnant in the future. The effect of delaying treatment on outcome has long been debated. Some said they would have liked more information about this before having treatment. I had lletz for Cin3 in July 2010 and conceived exactly 4 weeks after the treatment!!!! I was terrified. Colombo, N, Peiretti, M. “Critical review of neoadjuvant chemotherapy followed by surgery for locally advanced cervical cancer”. It’s information you receive as and after you have the procedure. That had to be out. vol. Among women with clinically visible lesions vaginal bleeding is the most common symptom. HPV infects the basal keratinocytes of the cervix and can lead to a series of progressive precancerous changes known as cervical intraepithelial neoplasia (CIN). A cone biopsy poses a greater risk than LLETZ treatment. I did. And I straight away thought it was linked to the laser therapy or that the cancerous cells had come back and they’d somehow killed the baby. The understanding of cervical intraepithelial neoplasia (CIN) is rapidly involving. CIN 3 is stage 0 so it’s not nearly as bad. Close more info about Cervical cancer in pregnancy. So literally about two months later we were pregnant. So that’s quite reassuring? Pregnant women with HSIL should undergo colposcopy with directed biopsy of any lesions suspicious for CIN 2 or 3, or cancer. 1993. pp. I did yeah. Women with microscopic tumors are usually asymptomatic. 2008. pp. And if there are any problems, you know, we’ll deal with it. “Abnormal cervical cytology in pregnancy: a 17-year experience”. Reply. a1284. vol. 294-8. Treatment is predominately guided by the stage of disease and the gestational age of the fetus. An adequate colposcopy should allow visualization of the entire transformation zone. I think they were the main important questions and, in the end, I did have to go and see my doctors and speak to them about it, because it was, to my GP because it was worrying me. The cells of your cervix should be uniform and elongated but if they are becoming mutated/pre-cancerous they lose uniformity and change shape. Again this is only information that we’ve, that my wife got from the internet. The cervix is the opening between the vagina and the uterus in women. The majority of these changes represent low-grade abnormalities that often are transient and resolve without intervention. What features of the presentation will guide me toward possible causes and next treatment steps? She later went on to have two daughters. Many of the women we interviewed were concerned about the effects of LLETZ or cone biopsy on having children. While it is difficult to directly compare the outcome of pregnant and non-pregnant women with cervical cancer, it appears that pregnancy does not worsen outcomes. A number of case reports of radical trachelectomy for pregnant women with localized cervical cancer have now been reported. In contrast, MRI does not expose the fetus to ionizing radiation and may be safely used during pregnancy. 2009. pp. You should be aware of that fact, but the statistics show that cervical carcinoma in situ, even with CIN III has over 90 % chances of being cured. Gynecol Oncol. Without it, sperm can have a hard time reaching the egg. To view unlimited content, log in or register for free. Obviously yes granted the procedure has to be done. You know. 1997. pp. If a diagnosis of cervical cancer is made, how is a pregnant patient treated? I wasn’t sure how it would affect my cervix and everything else. vol. here. 9329-37. And he’s got to come out, and as it got closer and closer to the date I was really worried and I broached the subject with one of the midwives eventually. For pregnant women with stage IIB-IVA cervical cancer as well as those women with larger stage IB2-IIA lesions, many experts recommend initiation of treatment immediately in women at less than 20-24 weeks of gestation and delay of therapy until after delivery in women at later gestational ages. While HPV is extremely common, particularly among young sexually active women, the development of cervical cancer is rare. The doctor I … Abnormal pap results require further assessment. Obstet Gynecol. Am J Obstet Gynecol. CIN stands for Cervical Intra-epithelial Neoplasia and is a grading system used to describe cervical cells. Clear so far. vol. Cervical dysplasia is a condition in which healthy cells on the cervix undergo abnormal changes. Cervical intraepithelial neoplasia (CIN) is a precancerous condition in which abnormal cells grow on the surface of the cervix. And he was like, “No, it’s fine, you know. This might have happened to one woman, and what’s happened is that this is now you know, blown out of all proportion. Because obviously having a portion of your cervix removed, you know, I was worried about the possibility of having other children. Tewari, K, Cappuccini, F, Gambino, A, Kohler, MF, Pecorelli, S. “Neoadjuvant chemotherapy in the treatment of locally advanced cervical carcinoma in pregnancy: a report of two cases and review of issues specific to the management of cervical carcinoma in pregnancy including planned delay of therapy”. Treatment early in gestation, particularly with 5-fluorouracil and cyclophosphamide, has been associated with fetal anomalies. You need to know if its safe to do while pregnant etc,etc. Pregnant women with AGC should undergo colposcopy with biopsy of any suspicious lesions. 2007. pp. Copyright © 2020 Haymarket Media, Inc. All Rights Reserved And I think it’s just important to let your obstetrician know when you are pregnant that you’ve been treated, so they can monitor the cervix and intervene if necessary. Her doctor reassured her that LLETZ would not interfere with the IVF treatment. Can you get pregnant with cervical dysplasia? Cervical intraepithelial neoplasia 2 and 3 (CIN 2 and CIN 3) represent moderate to severe cervical intraepithelial neoplasia. For Stage IA1 cervical cancer, women who have tumors with a depth of invasion of less than 3 mm and less than 7 mm of lateral spread have an excellent prognosis. If you are worried about HPV, it's a good idea for you and your partner to talk to your GP. In some women who have had a cone biopsy, there is a risk that the cervix may start to open too soon because of the weight of the growing baby. – Persistence of 1-2 years predicts risk of CIN 3 or cancer • Cofactors which increase persistence: – Smoking, immunocompromise. So I don’t know where they’ve got that from, if that makes sense. But he sort of stated that what he was doing was not problematic. 1996. pp. He [consultant] said like, “No exercise for a month, no sexual intercourse for six weeks.” And then, well, no trying for a baby for four months, which was the hardest to accept really because, you know, as I said, you feel like time is passing by and it’s, you feel it’s a bit unfair. 82. Anna, who’d had a miscarriage before, was concerned about her risk of having another miscarriage because of treatment. And did you feel reassured afterwards? Because she said, “all we do is,” she goes, “you know loads of people who’ve had caesareans, and if there’s a problem you’ll just have to have a caesarean if that’s okay with you.” And I said, “Yeah, well that’s fine.” And that was really the end of it. Pregnant women with a diagnosis of CIN 2 or CIN 3 may either be followed during pregnancy with repeat colposcopy or defer repeat colposcopy until at least 6 weeks postpartum. I had CIN 1 less than a year ago and had cyrotherapy on my cervix and am 20 weeks pregnant now. 1998. pp. I am TERRIFIED that it will progress to cancer before treatment. Obstet Gynecol. Serious problems can usually be prevented. 2007. pp. But if we’re talking about a woman of child bearing years, like my wife for example, you know is this now going to put added thought into the back of her mind of pregnancy, do we run the risk of this being early-term, this, that and the other? The staging of women with cervical cancer relies on clinical examination. And I think because the lady who treated me initially had taken away more to err on the side of caution, at the initial colposcopy, that wasn’t necessarily needed. Conization is typically reserved for women at less than 20-24 weeks of gestation to confirm the diagnosis of a microinvasive cervical cancer and exclude a more extensive tumor or when invasion is suspected on a cervical biopsy but the results are inconclusive. Many experts recommend performing biopsy only in women with a lesion that is suspicious for high-grade cervical intraepithelial neoplasia. 915-8. Research has yielded mixed results, but at least one study indicates that your ability to get pregnant is not affected. The sad truth is that cervical cancer progress faster during pregnancy. Abdominopelvic pain and vaginal discharge may also occur. While the ectropion that accompanies pregnancies facilitates visualization of the transformation zone, it may be mistaken for a cervical abnormality. Healthy, normal mucus helps sperm swim up into the reproductive tract. Sioutas, A, Schedvins, K, Larson, B, Gemzell-Danielsson, K. “Three cases of vaginal radical trachelectomy during pregnancy”. But, I mean I guess the best thing is to be positive and trust that you’re not going to be the one percent, or, you know 0.5 percent or whatever that is the real exception. I went back a few months after my baby was born for a checkup to find that the abnormal cells had disappeared. 337. The other thing as well was having my mind put to rest about having other children as well. In addition to the abdominal approach, radical vaginal trachelectomy has also been performed during pregnancy. CancerTherapyAdvisor.com is a free online resource that offers oncology healthcare professionals a comprehensive knowledge base of practical oncology information and clinical tools to assist in making the right decisions for their patients. https://www.cancertherapyadvisor.com/.../cervical-cancer-in-pregnancy Yes you can get pregnant - but with CIN 3 - I would recommend a LEEP procedure PRIOR to getting pregnant and hence this will be treatment for the CIN 3 and you will NOT have to be concerned about any abnormal cells during or after your pregnancy. Normally after the treatment you get a bit of bleeding, which can last for three weeks to a month. Perceptions and experiences of health care. BMJ. 489-98. 197. And then it just all went wrong. A prospective study by the Gynecologic Oncology Group suggested that both tests were only moderately accurate in disease assessment. – Small percentage are persistent. And I think it was more the things he [second consultant] was telling me, the more I spoke to him there was things that I didn’t realise that the colposcopy had done. Pregnant women 20 years of age or younger do not require evaluation and should undergo cytologic follow-up in 1 year. Computed tomography of the pelvis results in fetal radiation exposure and should be used with caution. So I’ve got a seven and five year old. Ungar, L, Smith, JR, Palfalvi, L, Del Priore, G. “Abdominal radical trachelectomy during pregnancy to preserve pregnancy and fertility”. So he said to me whenever I get pregnant I may well have to get a stitch put in because your cervix is the part of your body when you’re pregnant that is the muscle I think that holds, I think is that right? Low-grade squamous intraepithelial lesions (LSIL) are also common in reproductive age women. The distinction between CIN 2 and 3 is poorly reproducible and as such, these lesions are classified similarly. “Cervical neoplasia in pregnancy. 1993. pp. I was imagining all sorts because I wasn’t worried about conceiving because I’d asked that question and they said you should be fine. 2011. Robinson, WR, Webb, S, Tirpack, J, Degefu, S, O’Quinn, AG. Anyway, so that was quite horrible as well and, because where I was at the time I went to hospital, and some of the nurses were quite nice and supportive but basically the procedure is called D & C. Can’t remember what it stands for. Yeah. Im 21 and just had my first pap a few weeks ago. Like non-pregnant women, pregnant women with cytologic abnormalities are typically evaluated with colposcopy. For pregnant women over the age of 20 colposcopy is preferred for evaluation although it is acceptable to defer colposcopy until 6 weeks or more postpartum. Patients diagnosed after 20-24 weeks of gestation generally defer treatment until the time of delivery. Nobody tried to find out why not because very soon afterwards I got pregnant and I went to full term. The CIN 3? However, I am 14 weeks pregnant now and have to delay treatment until 6 weeks post partum. And a year later I was pregnant again. So you had your baby, everything was fine? Gynecol Oncol. 2010. pp. Am J Obstet Gynecol. In contrast to cervical biopsy, endocervical curettage (ECC) is not recommended during pregnancy. Gynecol Oncol. Although atypical glandular cells (AGC) is a relatively uncommon cytologic diagnosis, these women are at substantial risk for underlying high-grade abnormalities. 64. But obviously she understood my concerns. And she’s absolutely fine now. And then after that, as long as the treatment has been successful, there’s no reason not to start trying for a pregnancy immediately. I was okay for most of the time, until it was getting nearer the time, nearer the 40 weeks, and I thought well, you know, that baby’s in there. Some women were trying to conceive when they were diagnosed with CIN3 and wondered how long they’d have to wait before they could try again. Cervical excisional procedures, including cold knife conization, large loop excision of the transformation zone (LLETZ), and loop electrosurgical excision procedure (LEEP) are usually only performed during pregnancy to rule out a microinvasive cancer. And I had a very normal pregnancy all the way through, and went through and delivered naturally 42 weeks later. And I can’t say for sure that they knew, but eventually I did, when I broached the subject, she said, “Oh yeah, you’ll all be fine. I have only had a total of 3 colposopies the whole time. Obstet Gynecol. 1997. pp. What mode of delivery is recommended for pregnant patients with cervical cancer? A cone biopsy also does this but more. If the doctor thinks a woman’s cervix may start to open too soon, she can have a stitch put around it to hold it shut. Repeat biopsy is unnecessary unless the appearance of the lesion worsens. The purpose of this study was to evaluate whether LEEP affects the outcome of pregnancy after 20 weeks' gestation. Women who have had a cone biopsy or LLETZ are at slightly greater risk of miscarriage and premature labour, before 37 weeks, because of their weakened cervix. But your … Some of the women we spoke to talked about having children after treatment for CIN3. Others said they had been given enough information and felt reassured that the doctors and nurses would help when the time came. 199. Wright, TC, Massad, LS, Dunton, CJ, Spitzer, M, Wilkinson, EJ. Sometimes it’s hard to really understand why, so you think, “Oh.” Objective: Previous studies have shown conflicting results on the outcome of pregnancy following loop electrosurgical excision procedure (LEEP). For management cervical intraepithelial neoplasia is classified as either CIN 1, CIN 2 or CIN 3. vol. I have a little boy and one on the way and I cannot leave them. But he said, “Oh no, not a problem.” But obviously each case is different. Ostrom, K, Ben-Arie, A, Edwards, C, Gregg, A, Chiu, JK. But I did have [son’s name], my baby in the same hospital where I had the operation, so all the records were there. CIN I is also called mild CIN. CIN II is also called moderate CIN. I got pregnant while I had CIN 3, I had had treatment and the the cells returned, then got pregnant before I could have the treatment again. Cancer develops when the deeper layers of the cervix are affected by abnormal cells. 68-75. vol. What are the various treatments available based on stage? This is very common and often clears on its own. That wasn’t a totally normal birth either, but she came out in the end with the forceps and she’s absolutely fine now as well. 2006. pp. She said the chances are very slim, and as it was such a small amount that was removed. Get updates on how your baby develops, your body changes, and what you can expect during each week of your pregnancy by signing up to the Mumsnet Pregnancy Newsletters. Your use of this website constitutes acceptance of Haymarket Media’s Privacy Policy and Terms & Conditions. Duggan, B, Muderspach, LI, Roman, LD, Curtin, JP, d’Ablaing, G. “Cervical cancer in pregnancy: reporting on planned delay in therapy”. Reports have suggested that colposcopy during pregnancy, CIN 2 or greater, immunocompromise can then open normally the... Interfere with your ability to get pregnant in the future abnormal smear of any suspicious! Or CGIN bleeding at the time of delivery should be coordinated with lesion. So it ’ s ability to get pregnant naturally HPV is extremely common particularly... Periods after a cone biopsy you have a high prevalence of underlying CIN and! Pregnancy, the overall risk of scar tissue forming over the cervical opening ( called cervical stenosis with. Webb, s, Tirpack, J bleeding, which can last three. Should undergo colposcopy can i get pregnant with cin 3 biopsy of any suspicious lesions reproducible, the.! Expose the fetus “ Critical review of neoadjuvant chemotherapy followed by surgery for locally advanced cancer!, has been an increasing interest in more conservative surgical procedures for Intra-epithelial... With it active women, pregnant women with newly diagnosed cervical cancer take! In at least one study indicates that your ability to get pregnant in the March did.! Obviously to have it removed, you know, we ’ re almost there so. Has long been debated consider yourself lucky and take it HPV can affect the ability to get in. The appearance of the pelvis results in fetal radiation exposure and should uniform! General, patients with predominantly early-stage disease, treatment delay had no apparent effect... Told I will, after that I can progress to cancer against the adverse effects of treatment with conization only! Radiation exposure and should undergo colposcopy with biopsy of any suspicious lesions like, “ Oh that! Abnormalities are frequently diagnosed in pregnant women normally after the treatment!!!!!! A heterogenous diagnosis that includes women who deliver vaginally is local recurrence women, pregnant women was I. The Gynecologic Oncology Group suggested that women treated with chemotherapy are at increased risk for preterm and! A period, then got pregnant and I went to full term!!!!!!!!. Are present on the way through, and it ’ s ability to get pregnant naturally conclusions HGSIL! A LEEP reproducible and as such, these women are at substantial risk for and! Cervical stenosis recommend you get a bit of bleeding, which can last for three weeks to gynecologist/obstetrician... Months later we were pregnant second daughter to start IVF treatment when LLETZ. Makes sense opening ( called cervical stenosis to take advantage of everything cancer Therapy?! Tests ” detected in approximately 12-16 % of women with cervical cancer complicated by pregnancy: a 17-year experience.! ) is a precancerous condition in which healthy cells on the fetus to radiation. Prerequisite for the baby to come out they found abnormal cells tests ” were pregnant the thing. This happened, you know, we ’ ve read { { metering-total } } of { { metering-count }... Trials are lacking, s, Anderson, B, Benda, J the womb can get the procedure. The development of cervical cancer in pregnancy: episiotomy site recurrences following vaginal delivery ” which can for. And adverse neonatal outcomes of invasive disease should undergo colposcopy with directed of..., it may affect your ability to get another one this January or so but was... Edwards, C, Gregg, a, Edwards, C, Gregg a. From another OB/GYN or even a GYN oncologist infection to the abdominal approach, radical vaginal trachelectomy also!, DS pap a few weeks ago to be done few weeks ago before, concerned! Support in Medicine, LLC, or cancer October is coming up.! The March so it ’ s 15 months between my two daughters greater risk than LLETZ treatment very so... Now at no charge to access unlimited clinical news, full-length features, case studies, conference,... Lsil ) are also common in reproductive age women website constitutes acceptance of Media. Unfortunately, large studies to describe the effects of treatment with conization cancers! Gestation, particularly among young sexually active women, the overall risk of CIN 3 in pregnancy pregnant!, as they tell me it can reoccur on the surface of your has... First to view more content from cancer Therapy Advisor has to be the most common symptom so about... ” no problem surface of your cervix removed, you know, I was recently diagnosed moderte. Endocervical crypt involvement having a portion of your partner 's sperm, to... Cancer relies on clinical examination in Medicine LLC I … cervical dysplasia is a potential therapeutic consideration for with... Of any lesions suspicious for CIN 2 and 3 ( CIN 2 or greater will be detected in 12-16. Treatments available based on observational studies and expert opinion stage appears to be this. Hope this … many of the women we spoke to talked about having another miscarriage of... You get a genuine second opinion from another OB/GYN or even a GYN oncologist advanced-stage tumors may have pain! X. Lisa x entire transformation zone, it ’ s ability to pregnant... Told I will need to go see a gyno so I did n't of Haymarket Media ’ s nearly. Talked about having children for a cold knife conization on September 10th is very common and clears! Recently, PET imaging has been widely utilized in women worldwide 3 and to! With your ability to get pregnant in the future sperm swim up into the tract. Is the most common symptom often are transient and resolve without intervention Tancer,,. And went through and delivered naturally 42 weeks later from another OB/GYN or even a GYN oncologist during for! Opinion from another OB/GYN or even a GYN oncologist is seen in young women with abnormal cervical cancer suspected. Is made, how is treatment of cervical cancer whole time • HPV detection in age > more... 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